Home face a must-win game on Tuesday, with the potential to book a spot in the next round. The Serie A side can wrap up a top two finish if they win and Atletico Madrid beat Feyenoord in Rotterdam.
With a final day trip to the Spaniards on the horizon, Maurizio Sarri’s men can’t afford to slip up.
The good news for the hosts is that Celtic head to the Italian capital in awful form in Europe’s top competition.
They’re winless in 14 matches in the Champions League, losing 11 of those. Returning boss Brendan Rodgers has won just once in 21 games in this competition, losing seven of his last eight.
Lazio have won four of their last five home games, so they should be confident of seeing off the Bhoys.
However, the home side are missing their two starting centre-halves, while they’ve seen both teams score in 11 of their last 12 Champions League games.
Given that, Celtic are capable of getting a goal. However, they’ve lost four straight trips in Europe’s top tournament, conceding 16 times.